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To find out, he began giving exendin-4 to mice that had been made diabetic through overeatingand what he found was astonishing

The titration schedule for Ozempic and Wegovy is as follows: Ozempic (for type 2 diabetes or glycemic control): Weeks 1-4: 0.25 mg once weekly (starter dose, not yet effective for blood sugar, but helps your body adjust and reduces the risk of potential side effects.) Weeks 5-8: 0.5 mg once weekly Weeks 9-12: 1.0 mg once weekly Weeks 13 onwards: 2.0 mg once weekly (if further glycemic control is needed)

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Perioperative management : According to 2024 multi-society guidance, most patients can continue GLP-1 receptor agonists perioperatively, though individualized risk assessment is recommended, particularly for major gastrointestinal surgery or procedures with high aspiration risk