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One prominent mechanism is the downregulation of major histocompatibility complex class I (MHC-I) molecules on tumor cells, which impairs antigen presentation and reduces the visibility of malignant cells to cytotoxic T lymphocytes ( The expression of immune checkpoint molecules, including PD-L1, provides another layer of immune evasion

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The PPI network of the target genes was created using STRING ( and the pathways were assessed via Reactome analysis for enrichment

doi: 10.1007/s00417-008-1004-3

(2018) may help to identify who is most at risk