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SIRT1 function is also modulated through protein-protein interactions: DBC1 inhibits SIRT1 activity via complex formation, 30,49 whereas AROS and SENP1 interact with SIRT1 to enhance its activity, expanding the spectrum of functional regulation

In addition to these factors, a diet low in fiber can exacerbate the issue, leading to constipation and straining

Physical activity accelerates weight loss and improves metabolic health beyond what medication alone can achieve

Erastin, a ferroptosis activator, significantly attenuated the neuroprotective effects of treadmill training in rats with cerebral ischemia-reperfusion injury (Liu et al., 2022b)

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