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Semaglutide is a GLP-1-only agonist, while tirzepatide activates both GLP-1 and GIP receptors simultaneously, producing stronger appetite suppression and metabolic effects in many patients

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It is for patients with either: A body mass index (BMI) of 30 kg/m2 or greater A BMI of 27 kg/m2 or greater with at least one weight-related ailment such as type 2 diabetes, hypertension, sleep apnea, or others

This repositions GLP-1 receptor agonists like semaglutide 2.4 mg as true cardiometabolic therapies rather than just anti-obesity drugs

They typically describe one patient, and therefore do not demonstrate comprehensive proof of a drug effect for all users, only a one-off situation where this has occurred