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The calculator divides the target quantity by the total vial content, then multiplies by the water volume to give the exact draw volume in milliliters

Mechanism of Disease In cells missing the vital LAL enzyme, upregulation of cholesterol synthesis resulting from cellular dysfunction leads to ongoing lysosomal accumulation 1 LAL-D is characterized by Disrupted Cholesterol Metabolism and Intracellular Accumulation of Lipids Across Organ Systems 1,3 LAL-D LEADS TO PROGRESSIVE MULTISYSTEM ORGAN DAMAGE 2 LAL-D is characterized by disrupted cholesterol metabolism and intracellular accumulation of lipids across organ systems 2 Lipa Mutation 1 Missing or decreased LAL enzyme 1 Lysosomal accumulation of CE/TG 1 Dysregulated lipid metabolism 1 Liver 1,2 Hepatomegaly Hepatic injury ALT AST POSSIBLE/POTENTIAL CONSEQUENCes Microvesicular or mixed steatosis Fibrosis Cirrhosis Portal hypertension Liver failure HEART 1,2 Dyslipidemia LDL-C HDL-C POSSIBLE/POTENTIAL CONSEQUENCes Accelerated atherosclerosis Coronary artery disease Stroke Myocardial infarction Spleen 1,2,4 Splenomegaly POSSIBLE/POTENTIAL CONSEQUENCes Anemia Thrombocytopenia Risk of traumatic rupture and/or splenectomy Intestine 1,2 Intestinal lipid accumulation POSSIBLE/POTENTIAL CONSEQUENCes Abdominal pain Malabsorption Growth failure Abbreviations: ALT, alanine aminotransferase

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DHT-mediated follicle miniaturization drives this process

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