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Wang L, Wang H, Morizono H, Bell P, Jones D, Lin J, McMenamin D, Yu H, Batshaw ML, Wilson JM (2012) Sustained correction of OTC deficiency in spf (ash) mice using optimized self-complementary AAV2/8 vectors

Figure from Rossing et al NDT 2023 Primary Outcome This was a composite of time of first occurrence of: Onset of kidney failure (persistent eGFR 28 days or initiation of long-term KRT, kidney transplantation) Persistent 50% reduction in eGFR from baseline Death from kidney or CV causes Secondary Outcomes Confirmatory secondary outcomes were analyzed hierarchically

Plasma metabolomic biomarker panel to distinguish patients with amyotrophic lateral sclerosis from disease mimics

It helps regulate blood glucose, increases glucose uptake into cells and slows the gastrointestinal, or GI, tract to maximize nutrient absorption

These medications are typically administered once weekly through subcutaneous injections and are part of a comprehensive treatment plan that focuses on nutrition, movement, and lifestyle