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Lastly, the results of a very recent systematic review and network meta-analysis aimed to compare the effects of oral antidiabetic drugs in endocrine and metabolic profiles in patients with PCOS confirmed that metformin was more beneficial in reducing serum total testosterone, whereas GLP-1RA + metformin reduced FAI more effectively [24]

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Effects of Copper Overload on Methylation and Glutathione Pathways Copper overload can have a significant impact on the methylation pathway