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Januvia is generally better tolerated, with common side effects including upper respiratory infections, headaches, sore throat, and runny nose
A combined approach utilizing dual agonists or co-loaded nano-capsules has completely restored mucosal integrity in L-cell ablated mice, underscoring the complementary reparative roles of GLP-1 and GLP-2 (90, 91)
Wegovy should not be used with other weight loss interventions or GLP-1 receptor agonists (Ozempic, Mounjaro, or Zepbound), as this may increase the risk of side effects
Clinically, retatrutide is the most advanced triple agonist, with network meta-analyses identifying it as achieving the greatest weight reduction in the incretin class to date
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