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Critical structural modifications, such as C-terminal amidation and the presence of histidine at position 7, enhance their therapeutic efficacy and extend their half-life
Thus, it is attractive to hypothesize that GLP-1 signalling could enhance flux through the glycolytic pathway to generate metabolic stimulus-secretion factors
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GLP-1RAs, such as exendin-4 and liraglutide, can reduce neuroinflammation caused by microglia by encouraging a conversion from the pro-inflammatory M1 subtype towards the anti-inflammatory M2 phenotype
10.15252/emmm.201606932 97 DnuA.DumitrescuL.LefterA.TulbD.PopescuB
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