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Dipeptide cleavage is carried out by a catalytic triad (Ser630, Asp708, His740)
Regarding the participants with MCI or AD, defined based on a clinical dementia rating (CDR) global score of 0.5 or 1, although the 18-month treatment with exenatide was safe and well-tolerated, it did not significantly affect clinical and cognitive measures, nor did it affect MRI cortical thickness and volume or most biomarkers in the cerebrospinal fluid (CSF), plasma, and plasma neuronal extracellular vesicles (EVs)
The platform's role is to coordinate the patient experience: online intake, scheduling, payment processing, the communication infrastructure between patient and clinician, and shipping coordination with partner pharmacies once a prescription has been written
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