Alternatives to semaglutide include other classes of diabetes medications like metformin, sulfonylureas, DPP-4 inhibitors, and SGLT2 inhibitors
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Treatment of cells with GYY4137, an exogenous donor that releases H 2 S with slower kinetics, also inhibited both GLP-1 and PYY release (43 4% inhibition in GLP-1 release and 68 6% inhibition in PYY release with 10 mM GYY4137) (Figures 6A,B)
82,88 Alopecia, mainly attributed to accelerated telogen effluvium secondary to rapid weight loss, also has been reported, although hair loss is not officially listed as an adverse effect of GLP-1 agonists, and reports are highly variable
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