Based on published Phase 2 trial data, the most common adverse events are gastrointestinal: nausea (up to 46%), diarrhea (up to 33%), vomiting (up to 22%), and decreased appetite (up to 22%)
Eli Lilly's New Drug Application is expected in the Q4 2026 to Q1 2027 window, with potential FDA approval in late 2027 to 2028
The liquid format also allows the product to be mixed with water or juice, which may fit more easily into existing hydration or wellness routines
This leads to the changes seen after a certain degree of weight loss has occurred, such as volume loss in the temples and cheeks and dull, sagging skin, says Dr
In a study, people who stopped Zepbound after 9 months (36 weeks) regained 14% of their lost weight