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Tirzepatide has not yet completed a comparable cardiovascular outcomes trial, though studies are underway and early signals are promising
That warning stems from animal studies that suggested a possible increased risk, though more recent research published in 2025 suggests the same risk may not apply to humans
REDEFINE 2 -- CagriSema in T2D (Lingvay et al., 2025): Significant weight loss and glycemic improvement in adults with overweight/obesity and type 2 diabetes
However, prior to taking such medication, a doctor should be consulted first
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