These medications are not appropriate for everyone
Quick Answer: Leg cramps are not listed as an official side effect of semaglutide in FDA labeling, but may occur indirectly through dehydration, electrolyte imbalances, or nutritional changes associated with treatment
It also can act as an antioxidant, protecting against brain damage and keeping the nervous system youthful
It is known that exenatide, an exendinbased molecule, provides smaller average weight effects than semaglutide in headtohead and pooled comparisonslikely reflecting differences in receptor potency, exposure profile, and possibly central nervous system engagement [25]
Tirzepatide (dual GIP/GLP-1 agonist, not yet formally approved for obesity in the EU): in the SURMOUNT-1 study, resulted in an average weight loss of up to 22.5% at 72 weeks with the 15 mg weekly dose, approaching the effectiveness observed with some bariatric procedures