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Tirzepatide may be considered for its approved metabolic indications in these patients, but it should not replace or delay established autoimmune disease treatments
That said, it received an FDA warning letter over misleading marketing in February 2026 and holds a BBB F rating for failing to respond to complaints
Retatrutide : Early trials reported weight loss results up to ~ 24% over 48 weeks among the strongest yet observed in metabolic-medication research
However, more research is needed to draw firm conclusions about its effectiveness for back pain and other musculoskeletal conditions
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