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However, serious adverse effects can occur, including pancreatitis (severe persistent abdominal pain), gallbladder disease, and acute kidney injury (typically related to dehydration from gastrointestinal symptoms)

Note changes in appetite or blood sugar levels (if applicable)

With better insulin signaling, adipose tissue releases fatty acids more efficiently during exercise

The STEP clinical trial program demonstrated semaglutide 2.4 mg weekly produced sustained weight loss of 1522% over 68 weeks in adults with obesity, with 5065% of participants achieving 15% or greater weight reduction

Why this may happen: A high BMI is one lifestyle factor that can make it harder to get pregnant