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For current practice, the most defensible use of GLP-1RAs is as a time-bounded metabolic optimization strategy in women with meaningful obesity/insulin-resistance burden, with reproductive endpoints interpreted as potential downstream gains rather than guaranteed direct effects (17, 111, 112, 124)

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2.3.2 Immune cell recruitment inhibition Apart from inflammatory cytokines secretion reduction, inhibited macrophage infiltration and immune cell recruitment also played a vital role in GLP-1RAs anti-inflammatory ability

Wolf Horrell EM, Boulanger MC, D'Orazio JA