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Curr Opin Neurol 30(3):310316 Crisp SJ, Dixon CL, Jacobson L, Chabrol E, Irani SR, Leite MI, Leschziner G, Slaght SJ, Vincent A, Kullmann DM (2019) Glycine receptor autoantibodies disrupt inhibitory neurotransmission

Why this matters for dosing The extended half-life means: Once-weekly injections are sufficient the drug does not need to be taken daily Steady-state levels build up over several weeks this is another reason why gradual titration works well

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In contrast, ghrelin, which is secreted from gastric epsilon cells, promotes hunger

But its also available in oral form