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Linagliptin significantly increased LS-mean insulin response to OGTT by 55% (95% CI 39.05, 71.74%) in the high GLP-1 compared to 12% (95% CI -4.05, 29.01%) in low GLP-1 group, resulted in a significant between-group difference (p = 0.002) ( Figure 3F )

Menopause-Specific Data Clinical trials involving postmenopausal women illustrate this point as weight loss is more difficult during this time due to hormone shifts, a slowing metabolism, and recalcitrant belly fat

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