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In clinical trials, the 12 mg maintenance dose produced 24.2% body weight loss at 48 weeks (Phase 2) and 28.7% at 68 weeks (Phase 3)
Fat is the primary target
151 While preclinical/clinical studies suggest that the dual/pan-PPAR agonists have a more significant effect in the treatment of disease when compared with PPAR or PPAR agonists alone, improvement of the low agonistic activity and low metabolic stability of multiple agonists may still need to be improved
In preclinical models, this nanoplatform effectively reduces MDSC populations, reactivates antitumor immunity, and inhibits tumor growth with a favorable safety profile (31)
Moreover, insulin does not appear to be associated with prostate cancer risk [4]
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