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Robledinos-Antn et al., 2019
These neurofunctional changes can start an autovicious cycle in which various systems and mechanisms are exacerbated and accelerate cell damage, resulting in progressive structural brain changes and impairment of frontal cognitive functions
However, this general metabolic support should not be conflated with specific effects on GLP-1 secretion
You may notice reduced hunger and food cravings withing the first few weeks as your dose increases
One example escalation schedule observed in Phase 2 obesity trials proceeded broadly as follows: Weeks 14: 2 mg once weekly (initiation phase) Weeks 58: 4 mg once weekly Weeks 912: 8 mg once weekly Weeks 13 onwards: Up to 12 mg once weekly (the maximum dose explored in Phase 2 trials) This is an illustrative example only
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