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Source: NIH Office of Dietary Supplements [1]

Important safety considerations include: Risk of acute pancreatitis: urgent medical review needed for severe, persistent abdominal pain (with or without back pain) Gallbladder disorders: seek medical advice for symptoms of gallstones (right upper abdominal pain, nausea) Diabetic retinopathy complications: particularly with semaglutide in those with pre-existing retinopathy Hypoglycaemia: risk is low unless combined with insulin or sulfonylureas, which may require dose adjustment Reports of mood changes and suicidal ideation in patients taking GLP-1 receptor agonists are being monitored by regulatory authorities

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Giving exogenous GLP-1 analogues or increasing endogenous GLP-1 levels can enhance the signaling of GLP-1R, and the activation of GLP-1R can effectively inhibit glucagon secretion in human body