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The available evidence suggests that such biotechnological methods not only increased the quantity and availability of PPs for industrial, food and medicinal purposes (360, 381, 382), but also expedited the number of scientific investigations conducted on PPs to find the most potent metabolites for large-scale applications (361)

The Summary of Product Characteristics does not include sleep disturbances, insomnia, or related terms among the documented adverse reactions from clinical trials or post-marketing surveillance data

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