Not painful Once the needle is through the skin, there are few nerve sensors, making the injection almost painless
10.1016/j.conb.2012.02.005 Curr
In a randomized, double-blind, placebo-controlled crossover trial of 30 adults with obesity (Effects of once-weekly semaglutide on appetite, energy intake, control of eating, food preference and body weight in subjects with obesity, Blundell and colleagues, Diabetes, Obesity and Metabolism , 2017), 12 weeks of once-weekly semaglutide titrated to 1.0 mg was associated with less hunger, fewer food cravings, better control of eating, and a lower preference for high-fat foods
The cost of semaglutide without health insurance can depend on the specific product, dosage, and pharmacy you get it from
Monitoring and Follow-up Regular monitoring of blood glucose levels (for patients with diabetes), body weight, and overall symptom burden helps identify issues early