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Antiplatelet effect of capsaicin

Although substantial weight loss can reduce pathological joint loading and systemic inflammation, the direct pharmacological effects on synovial fibroblastsattenuating their inflammatory signalling and fibrotic activation may offer an additional, disease-modifying and analgesic mechanism that targets the local synovial environment, driving pain and structural progression

Overweight individuals with T2DM should reduce energy intake while maintaining a balanced diet rich in nutrient-dense foods like fruits, vegetables, whole grains, lean proteins, and healthy fats, limiting added sugars, sodium, and saturated fats [148]

Although energy intake and dietary composition did not differ between groups in our study, a protein intake 1.0g/kg/ day may limit the extent of adaptation to RET (57)