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Biological toxins might act as health hazardous diabetogenic agents to disrupt normal function of the human body in controlling blood sugar levels and associated signaling pathways (212)

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Interestingly, while the exposure of brain microvascular endothelial cells to the HIV-1 Tat protein leads to decreased expression of claudin-1, claudin-5, and ZO-2, the expression of ZO-1 and occludin remains unchanged [186]

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placebo on body fat mass among adults with type 2 diabetes and obesity: a phase 2 randomized clinical trial