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Some studies indicate that the reduction in body fat can lead to decreased collagen density in the skin, making it more prone to sagging over time
doi: 10.1210/jc.2010-2679 47 HjelholtAJLeeKYArlien-SborgMCPedersenSBKopchickJJPuriVet al
FGF21, a protein implicated in fat and sugar utilization, decreased at higher doses, which may indicate enhanced metabolism
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