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The researchers noted that compared with the control group, the epithalamin-treated patients exhibited [10]: Decelerated aging of the cardiovascular system Decreased rate of cardiovascular mortality and cardiovascular failure (-50%) Less age-associated impairment of physical endurance Normalized circadian rhythm for melatonin production Normalized circadian rhythm for lipid (fats) and carbohydrate metabolism Lower rate of mortality (-28%) The follow-up study on long-term epithalamin treatment represents strong evidence of eptithalons favorable safety profile and relative absence of notable epithalon side effects

Physiology, Growth Factor

Authors: Tiiu Kullisaar, Jelena Shepetova, Kersti Zilmer, Epp Songisepp, Aune Rehema, Marika Mikelsaar, Mihkel Zilmer Subjects: One hundred clinically healthy volunteers (75 females, 25 males, age 40-65 years) were recruited into a double-blind placebo-controlled randomized study

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The global impact of diabetes is closely connected to the development of early insulin resistance, which stems from impaired signaling at the insulin receptor (INSR)