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In vitro experiments demonstrated that Akt inhibition markedly upregulated the expression of FTL, FTH, TFR1, and Poly (rC)-binding protein 1 (PCBP1), downregulated FPN1 expression, increased APP expression, enhanced iron storage and uptake, and decreased iron efflux, thereby aggravating neurological injury in SH-SY5Y and C2C12 cells (Halon-Golabek et al., 2024)

But FDA scientists said they could find little data on the medical use of BPC-157 and raised concerns about risks of contamination, allergic reactions and quality control

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In confirmed pernicious anemia, treatment is lifelong

"Peptides need to be from a physician and a compounding pharmacist, and not, from what I've heard, a business card in the men's bathroom," said Elizabeth Yurth, co-founder of the Boulder Longevity Institute