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Gallbladder disease : Rapid weight loss may increase the risk of cholelithiasis (gallstones) and cholecystitis
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Injectable formulations avoid direct oral tissue contact but produce the same downstream effects on saliva production through systemic GLP-1 receptor activation
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3,4 Excess body fat raises blood pressure and inflammatory markers, and contributes to obstructive sleep apnoea
Treating diabetes mellitus in Prader-Willi syndrome with exenatide
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![Physiologic effects of GLP-1 (adapted from Granata et al. [11])](https://www.researchgate.net/publication/359199250/figure/fig1/AS:11431281081130351@1661532031197/Physiologic-effects-of-GLP-1-adapted-from-Granata-et-al-11.png)
