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ALP, osteocalcin, type I collagen, Runx2, and osterix are examples of osteoblast differentiation indicators whose mineralization and expression are inhibited by rutin treatment, whereas adipogenic markers are increased (134)
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This fat reduction is achieved through mechanisms such as improved insulin sensitivity and enhanced lipid metabolism
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Berberine dosage : Clinical studies have typically used doses ranging from 900mg to 1,500mg daily , usually divided into two or three doses taken with meals
