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Two-fold concentrated stock solutions containing either 2 mM Aldrithriol-2 (Sigma-Aldrich, Darmstadt, Germany, CAS-2127-03-9, AT-2) (oxidation control), 10 mM Dithiothreitol (Sigma-Aldrich, Darmstadt, Germany, CAS-3483-12-3, DTT) (reduction control), 5 mM reduced glutathione (GSH, Sigma-Aldrich, CAS-70-18-8, pH 7.4 in 1 M HEPES), 5 mM oxidized Glutathione (GSSG, Sigma-Aldrich, CAS-27025-41-8, pH 7.4 in 1 M HEPES) or HEPES were prepared freshly

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A July 2024 study from Mass Eye and Ear (published in JAMA Ophthalmology) found that patients with diabetes taking semaglutide were 4.28 times more likely to develop NAION compared to those on other diabetes medications

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Taking it before, during, or after a meal will have a negligible, if any, impact on its bioavailability and subsequent effectiveness in a research setting