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HGF binding to c-Met induces the activation of downstream signal mediators, including ERK (You et al., 2011), c-Jun N-terminal kinase (JNK) (Rodrigues et al., 1997) and AKT (Zhang et al., 2018c)

TIP3P water molecules 49 were added to the simulation box (final dimensions 126 x 126 x 186 ) using the VMD Solvate plugin 1.5 (VMD Solvate plugin, Version 1.5

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Allowing the injection solution to reach room temperature before administration may reduce discomfort