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Moreover, HMG decreased GSH concentrations and altered the activities of antioxidant enzymes, which were also mitigated by MK-801 [106], indicating a role for NMDAR in these effects

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The AEOL series and pentaazamacrocyclic ligand-based mimetics (SC series and M404 series), on the other hand, are more specialized toward O 2 (though many can also address other ROS as well) and generally lack catalase-like activity (targeted to eliminate H 2 O 2 ), and this may limit their therapeutic use (e.g., to more acute conditions such as lung injury or effects of ionizing radiation) (Liang et al., 2007

Results of cytokine expression are summarized in Fig