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Smith J, Lopez R, Patel M, et al
In vitro experiments (organotypic hippocampal culture exposed to oxygen and glucose deprivation), the culture treated with berberine has less cellular death
However, this conformational change reduces the space available to accommodate the -helix of the peptide increasing the steric hindrance between the bulky ionic lock (R17 Cagri- E14 Cagri ) and ECL2
In fact, they not only complement one anothers functions but also support each other
Is it symptom-modifying, or is it truly disease modifying
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