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Insulin-like growth factor 1 (IGF-1): a growth hormone
In a comparative study the size dependency of BBB uptake and permeability was investigated for nanoparticles from 50 to 500 nm of various composition (polystryrene, protein, lipid) on a human culture BBB model in which transferrin nanocarriers with 500 nm diameter showed the most successful BBB penetration [61]
The GSTP1 rs4147581 is in linkage disequilibrium with rs1695 (D = 0.99, R 2 = 0.44 in Admixed American populations, including Colombians), a common nonsynonymous SNP that changes the 105th amino acid from isoleucine to valine, altering the substrate binding site of GSTP1 38
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