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The pattern we see most often in patients with prior bariatric surgery is good tolerability at 0.25 to 0.5 mg but rapid symptom escalation at 1 mg or higher
Canadian Agency for Drugs and Technologies in Health (CADTH) with INESSS's permission
But that caloric deficit creates a metabolic challenge: rapid mobilisation of adipose tissue releases free fatty acids into circulation faster than the liver can process them without sufficient lipotropic cofactors
Even at lower doses, patients often see reductions in fasting glucose and improved post-meal sugar control
Key methods: Extraction of IGE reports labeled under the term impaired gastric emptying in MedDRA
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