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IGF-1 availability is tightly regulated by the so-called insulin- like growth factor binding proteins (IGFBPs), which may act by increasing IGF-1 half-life, from minutes to hours (most commonly by forming a tertiary complex with Acid-Labile Subunit and IGFBP3), however blocking its binding to the insulin-like growth factor 1 receptor (IGF- 1R) [7]

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Statistical methods Conditional logistic regression was used to calculate multivariable odds ratios (OR) and 95% confidence intervals (CI) for the association of ALS with quartiles of serum IGF-1 concentrations

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For semaglutide specifically, treatment should be discontinued at least 2 months before a planned pregnancy