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An agonist is any artificially produced substance that can attach to cell receptors and perform the same function as the naturally occurring substance it is designed to mimic

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They included 12 SGLT2i trials with 73,238 participants, of whom 3,065 were on a GLP-1 RA: they found that the benefits of SGLT2i on MACE were consistent regardless of background GLP-1 RA use (HR = 0.81 in patients receiving GLP-1 RA vs HR = 0.90 in those not receiving GLP-1RA) with no significant heterogeneity (p = 0.31)