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The role of pH in stability Research indicates that tirzepatide stability is optimized in a pH range of 4 to 5 for storage formulations, though some studies suggest broader stability up to pH 8.5 depending on the specific buffer system used
Phase 2 trial (NEJM, 2023) The landmark Phase 2 trial, published in the New England Journal of Medicine, randomized 338 adults with obesity to receive weekly subcutaneous retatrutide at doses of 1 mg, 4 mg, 8 mg, or 12 mg, or placebo, for 48 weeks
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