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Maraldi T et al
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Sickle cell anemia is an inherited blood disorder characterized by both a deficiency of healthy red blood cells and painful episodes called sickle cell crises
The article highlights research findings that link NNMT inhibition to improved metabolic markers, reduced adipose tissue, and better overall energy balance, making 5-Amino-1MQ a promising tool in metabolic and obesity-related studies
The interest traces to a 2014 Nature paper showing that knocking down NNMT in fat and liver protected mice against diet-induced obesity, glucose intolerance, and fatty liver, partly by shifting adipose NAD+ and SAM levels [4]
Finding the real cause of tinnitus is important for treatment
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