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Physiologically based pharmacokinetic modeling for chlorinated paraffins in rats and humans: Importance of biliary excretion
[10] This low-dose approach contrasted with earlier trials that used much higher doses (e.g., 138 mg or 228 mg daily), which did not significantly outperform placebo
All these trials were designed to evaluate the primary outcome of 3-MACE defined as cardiovascular death, nonfatal myocardial infarct, and nonfatal stroke, except for the ELIXA trial of exenatide ER, which included hospitalization for unstable angina as an additional component of the 4-MACE composite outcomes
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