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MMPs are enzymes that break down the extracellular matrix necessary for remodeling damaged tissue, but problematic when elevated chronically

In addition, TB-500 ensures that fibroblasts have enough actin to make use of their extended lifespans

Drugs much smaller have low oral bioavailability due to difficulty in getting through the gut wall Even if AOD9604 was only a small peptide, it would still be susceptible to enzymatic degradation in the gut, being derived as it is from a naturally occurring protein12

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If the protocol feels inconvenient, that's the cost of maximising outcomes