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2015;10(11):e0140963
Key Takeaways Both Mounjaro and compounded tirzepatide share identical chemical structures and molecular formulas, containing the same 39-amino acid polypeptide
This 39-amino acid peptide showed structural similarity to human GLP-1, sharing approximately 53% sequence homology
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In one phase 2 study: Pancreatitis was reported in about 0.4% of participants (1 out of 267) Gallbladder issues affected roughly 1.1%, with no cases in the placebo group Heart rhythm changes were reported more often in people taking retatrutide (about 6% compared to 3% with placebo) Liver enzyme increases were rare (around 1%), and overall liver health markers stayed stable over time
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