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B6 mice fed with a normal fat diet (Normal Diet) or HFD (DIO) received the following treatment regimens: saline (Saline), scExe4 donor DNA-loaded LNP (Donor), or scExe4 donor DNA plus Cas9-coding DNA-loaded LNP (Donor+Cas9)

and Lindstedt, G

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[17] Supporting Muscle Preservation During periods of caloric restriction, maintaining muscle mass becomes challenging

These findings indicate that continuous Exe4 secretion via genome editing does not substantially suppress endogenous GLP-1 secretion