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The mouse in biomedical research
A., & Akhondzadeh, S
Ozempic (semaglutide) is a GLP-1 receptor agonist licensed in the UK for type 2 diabetes mellitus treatment
Merck's MK-0893, a small-molecule GCGR antagonist, reached Phase 2b in type 2 diabetes and showed meaningful HbA1c reductions - alongside dose-dependent LDL cholesterol increases, transaminase elevations, and modest weight gain that together made the molecule untenable as a chronic medicine
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