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This review will discuss the contribution of integrins to the mechanisms regulating microtubule nucleation at the centrosome and microtubule stabilization at the cell cortex both during cell migration and the establishment of apicalbasal polarity, as well as the current understanding of how the assembly and turnover of integrin-mediated adhesions is regulated by changes in the microtubule cytoskeleton

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Connective tissues include: Tendons Ligaments Fascia Cartilage support structures Skin matrix Joint-supporting tissues These tissues heal slowly because they often have limited blood supply