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It also carries a cardiovascular-event-reduction indication
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Although an early pilot study with ketotifen (an H1R blocker and MC stabilizer) showed some efficacy in a small subset of pediatric UC patients, 33 the role of histamine receptors in the pathogenesis of colitis has remained unclear, with no clear role for H1R, 34, 35 a proposed protective role for H2R via microbial crosstalk, 35, 36 and preclinical evidence of a proinflammatory role for H4R