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In agreement with previous reports (36), acute (1 hour) beta cell exposure to high cholesterol leads to increased insulin secretion under 11 mM glucose conditions, but the GLP-1R is unable to further potentiate secretion to the same extent than with unmodified cholesterol levels

Granhall C, Donsmark M, Blicher TM et al (2019) Safety and pharmacokinetics of single and multiple ascending doses of the novel oral human GLP-1 analogue, oral semaglutide, in healthy subjects and subjects with type 2 diabetes

This was not only because of the impact of GLP-1 on obesity but also because of their ability to help with so many other conditions

In fact, plateaus often provide a useful opportunity to reassess your habits, expectations, or dosing with your clinician