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It raises the possibility that these drugs may have broader anti-inflammatory or cardiometabolic effects, which is particularly interesting in a systemic inflammatory disease such as HS. According to Jastrzb-Mikiewicz, patients with HS are frequently diagnosed with obesity, insulin resistance, diabetes, and other metabolic comorbidities, making GLP-1s particularly relevant for this population

Antioxidant functions Glutathione reductase is a FAD-dependent enzyme that participates in the redox cycle of glutathione

However, retatrutide is still under study and not yet FDA-approved, while semaglutide is widely available and approved for both weight loss and diabetes management

Most patients require several sessions to achieve their desired results

Extracts enriched in different polyphenolic families normalize increased cardiac NADPH oxidase expression while having differential effects on insulin resistance, hypertension, and cardiac hypertrophy in high-fructose-fed rats